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  • Meier-Vollrath, I., Schneider, W., & Schmeller, W. (2005). Lipödem: Verbesserte Lebensqualität durch Therapiekombination. Deutsches Ärzteblatt, 7.

    Lipoedema: Improved Quality of Life by Combination of Therapies Lipoedema is a chronic progressive disease with increased fat volumes mainly of the legs, causing body disproportion together with orthostatic oedema, pain and bruising. Early diagnosis can be achieved by clinical symptoms. Complex physical therapy with manual lymphatic drainage, compression and physiotherapy reduces oedema and complaints. Surgical therapy with liposuction reduces circumscribed fat volumes, improves body proportions and diminishes oedema and bruising. Following surgery physical therapy can be diminished in intensity and number. Nowadays the combination of physiotherapy and liposuction is considered the optimal treatment regime which can tremendously improve the patient's quality of life.

  • Schmeller, Wilfried, & Meier-Vollrath, I. (2009). Lipoedema - Information Leaflet for Patients (p. 28). BSN Jobst.

    Dear Patient, although much has been published about lipoedema during the past decade, this disease continues to be relatively unknown; it is still overlooked and/or mistaken for obesity (overweight) or lymphoedema by many doctors. As a result, the information and therapy instructions given to afflicted individuals is often either incorrect or only partially covers the aspects of this disease. This brochure was designed to help you learn more about lipoedema and to enable you to evaluate and get the most benefit from available therapeutic options. All important information is presented concisely in the form of questions and answers. Please keep in mind that many aspects of this disease remain unclear to date. As with most other diseases (e.g. diabetes, high blood pressure, varicosis, rheumatism, etc.), the symptoms and discomforts are fairly well known, but the underlying causes are not. However, our insights have become much more extensive in the past few years. Since crucial progress has been made in recent years especially with regard to the treatment of lipoedema, there are some very effective measures now available that have a positive impact on all aspects of this chronic disease. This allows you to live a largely „normal“ life without major limitations, at a quality level that until recently was unthinkable. Meanwhile, a wealth of information has become accessible through the internet, where you can get help from specialised doctors, physiotherapists, and other patients afflicted by this disease. There is no longer reason for despair. With the compliments of BSN-JOBST® GmbH

  • Schmeller, Wilfried, & Meier-Vollrath, I. (2008). Lipedema (Chapter 7). In H. Weissleder, C. Schuchhardt, & R. G. H. Baumeister (Eds.), Lymphedema : diagnosis and therapy (4th ed., pp. 294–323). ViaVital Verlag, GmbH.

    Lipedemawas first described by Allen and Hines in 1940 (1).Today, however, a large number of physicians remain unaware of the disease and its symptoms. Many lipedema patients are not correctly diagnosed or effectively treated until after they have endured decades of suffering (2). Epidemiological statistics on the incidence of lipedema are not available. An investigation of patients treated at one lymphedema clinic from 1995 to 1996 revealed lipedema in approximately 15% of the patients treated on an inpatient basis (3). A similar number (8% to 17%) was reported in surveys carried out in 2003 in four lymphedema clinics in Germany (4). In contrast to lymphedema, literature on lipedema is extremely sparse. Lipedema findings in the Anglo-American literature in particular often report only isolated case studies (5-8). Many more publications, including a monograph, are available in German literature (9). Table 7-1 lists synonyms for lipedema.

  • Streubel, M. K., Baumgartner, A., Meier-Vollrath, I., Frambach, Y., Brandenburger, M., & Kisch, T. (2024). Transcriptomics of Subcutaneous Tissue of Lipedema Identified Differentially Expressed Genes Involved in Adipogenesis, Inflammation, and Pain. Plastic and Reconstructive Surgery. Global Open, 12(11), e6288. https://doi.org/10.1097/GOX.0000000000006288

    BACKGROUND: Lipedema is a disease typically affecting women with a symmetrical, painful fat distribution disorder, which is hypothesized to be caused by impaired adipogenesis, inflammation, and extracellular matrix remodeling, leading to fibrosis and the development of edema in lipedema subcutaneous adipose tissue. The pathogenesis and molecular processes leading to lipedema have not yet been clarified. METHODS: A whole transcriptome analysis of subcutaneous tissue of lipedema stages I (n = 12), II (n = 9), and III (n = 8) compared with hypertrophied subcutaneous tissue (n = 4) was performed. Further data about hormonal substitution and body morphology were collected. The study is registered at ClinicalTrials.gov (NCT05861583). RESULTS: We identified several differentially expressed genes involved in mechanisms leading to the development of lipedema. Some genes, such as PRKG2, MEDAG, CSF1R, BICC1, ERBB4, and ACP5, are involved in adipogenesis, regulating the development of mature adipocytes from mesenchymal stem cells. Other genes, such as MAFB, C1Q, C2, CD68, CD209, CD163, CD84, BCAT1, and TREM2, are predicted to be involved in lipid accumulation, hypertrophy, and the inflammation process. Further genes such as SHTN1, SCN7A, and SCL12A2 are predicted to be involved in the regulation and transmission of pain. CONCLUSIONS: In summary, the pathogenesis and development of lipedema might be caused by alterations in adipogenesis, inflammation, and extracellular matrix remodeling, leading to fibrosis and the formation of edema resulting in this painful disease. These processes differ from hypertrophied adipose tissue and may therefore play a main role in the formation of lipedema.

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