Lipedema: what we don’t know

Resource type
Authors/contributors
Title
Lipedema: what we don’t know
Abstract
Background Lipedema is a loose connective tissue disease characterized by a disproportionate accumulation of adipose tissue in the limbs of women. Despite its incidence of 10-20%, lipedema is often underdiagnosed and misdiagnosed. Objectives This review aims to outline current available evidence regarding this enigmatic syndrome and gives a synopsis on the subjects that are still unknown. Materials and Methods PubMed and Embase searches were conducted to identify relevant articles on lipedema pathophysiology, clinical presentation, diagnosis and treatment. Results Lipedema can be considered a disease of the adipocytes or a circulatory disorder of the lymphatics. The relationship between lymphatics and adipose tissue remains controversial. The clinical distinction between lipedema, lymphedema, phlebolymphedema and lipolymphedema can be difficult. Diagnoses often coexist, further complicating the diagnosis of lipedema, which is currently made on clinical grounds alone. The value of diagnostic imaging studies is unclear. Liposuction appears to be an effective treatment and significantly improves symptoms. Conclusion Diagnosing lipedema remains a challenge due to its heterogeneous presentation, co-existing diseases, and the lack of objective diagnostic imaging. Further directions for research include the effect of excess skin resection surgery on lymphatic drainage.
Publication
Journal of Plastic, Reconstructive & Aesthetic Surgery
Date
2023-05-30
Journal Abbr
Journal of Plastic, Reconstructive & Aesthetic Surgery
Language
en
ISSN
1748-6815
Short Title
Lipedema
Accessed
6/27/23, 6:22 PM
Library Catalog
ScienceDirect
Citation
van la Parra, R., Deconinck, C., Pirson, G., Servaes, M., & Fosseprez, P. (2023). Lipedema: what we don’t know. Journal of Plastic, Reconstructive & Aesthetic Surgery. https://doi.org/10.1016/j.bjps.2023.05.056