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Lipedema Adipocytes in Culture: Signs of Hypertrophy, Inflammation, and Fibrosis

Resource type
Authors/contributors
Title
Lipedema Adipocytes in Culture: Signs of Hypertrophy, Inflammation, and Fibrosis
Abstract
<p id="p1">Despite extensive research during the last couple of years, lipedema still appears enigmatic in respect to its pathogenesis. In our in vitro study, we have set out to further characterize lipedema adipocytes, concentrating on gene and protein expression, which might help to develop ideas explaining the excessive accumulation of adipose tissue in women with lipedema. Using 2D cultures we show that gene expression in lipedema and non-lipedema adipocytes differs significantly in terms of genes related to lipid droplet size determination, insulin signaling and glucose uptake. A pronounced hypertrophy, recognizable by a significantly increased average lipid droplet size, was visible in differentiated lipedema adipocytes grown in 3D cultures. In addition, gene and protein expression related to inflammation and fibrosis were upregulated in lipedema adipocytes compared to controls, supporting earlier reports. Taken together, results from our in vitro studies suggest that lipedema adipose cells are capable of retaining their hypertrophic nature under culture conditions and open new aspects focusing on insulin signaling and PDGFRA-mediated balancing of adipogenic versus fibrogenic differentiation of lipedema adipose tissue.</p>
Publisher
IntechOpen
Date
2024/06/12
Language
en
ISBN
978-1-83769-340-5
Short Title
Lipedema Adipocytes in Culture
Accessed
7/8/24, 6:13 PM
Library Catalog
Citation
Ernst, A. M., Schimak, E., Steiner, M., Lipp, A.-T., Bauer, H.-C., Bauer, H., Ernst, A. M., Schimak, E., Steiner, M., Lipp, A.-T., Bauer, H.-C., & Bauer, H. (2024). Lipedema Adipocytes in Culture: Signs of Hypertrophy, Inflammation, and Fibrosis. IntechOpen. https://doi.org/10.5772/intechopen.1004241
Publication