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Steroid-converting enzymes in human adipose tissues and fat deposition with a focus on AKR1C enzymes

Resource type
Authors/contributors
Title
Steroid-converting enzymes in human adipose tissues and fat deposition with a focus on AKR1C enzymes
Abstract
Adipocytes express various enzymes, such as aldo-keto reductases (AKR1C), 11β-hydroxysteroid dehydrogenase (11β-HSD), aromatase, 5α-reductases, 3β-HSD, and 17β-HSDs involved in steroid hormone metabolism in adipose tissues. Increased activity of AKR1C enzymes and their expression in mature adipocytes might indicate the association of these enzymes with subcutaneous adipose tissue deposition. The inactivation of androgens by AKR1C enzymes increases adipogenesis and fat mass, particularly subcutaneous fat. AKR1C also causes reduction of estrone, a weak estrogen, to produce 17β-estradiol, a potent estrogen and, in addition, it plays a role in progesterone metabolism. Functional impairments of adipose tissue and imbalance of steroid biosynthesis could lead to metabolic disturbances. In this review, we will focus on the enzymes involved in steroid metabolism and fat tissue deposition.
Publication
European Review for Medical and Pharmacological Sciences
Volume
25
Issue
1 Suppl
Pages
23-32
Date
2021-12
Journal Abbr
Eur Rev Med Pharmacol Sci
Language
eng
ISSN
2284-0729
Library Catalog
PubMed
Citation
Kiani, A. K., Mor, M., Bernini, A., Fulcheri, E., Michelini, S., Herbst, K. L., Buffelli, F., Belgrado, J.-P., Kaftalli, J., Stuppia, L., Dautaj, A., Dhuli, K., Guda, T., Manara, E., Maltese, P. E., Michelini, S., Chiurazzi, P., Paolacci, S., Ceccarini, M. R., … Bertelli, M. (2021). Steroid-converting enzymes in human adipose tissues and fat deposition with a focus on AKR1C enzymes. European Review for Medical and Pharmacological Sciences, 25(1 Suppl), 23–32. https://doi.org/10.26355/eurrev_202112_27330
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