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Pain is an important criterion for diagnosing lipedema. This pain, however, has not been properly investigated or characterized in the literature, and in most cases, authors have settled for putting forward hypotheses. Comparison of these hypotheses with actual findings, if even available, it becomes obvious that many of these hypotheses cannot be correct. Hardly any of the tangible results seem to provide a solid basis for explaining lipedema-related pain. When examining lipedema-related pain reported in the pain literature, it becomes increasingly evident that dynamic mechanical allodynia, with Aß-fibers and probably tactile C (CT)-fibers, is Involved. It Is in principle possible to stimulate CT-fibers by manual lymphatic drainage (MLD), and this may explain the method's analgesic effects. Conversely however, this pain-relieving effect via CT-fibers seems to exclude the Involvement of small fiber neuropathy (SFN), and thus any direct nerve damage as the cause of pain in lipedema.