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Lipedema is a clinical condition in which there is abnormal swelling of body parts which may be confused with lymphedema and obesity. Allen and Hines first coined this term in 1940. It commonly affects lower limbs in symmetrical pattern. However asymmetric lipedema cases are reported also. Women are commonly affected. Diagnosis is mostly clinical. Imaging has important role in diagnosis and differentiating from closely related differentials. Conservative and surgical treatment are usually recommended. It is often misdiagnosed due to lack of proper knowledge and investigated in an inappropriate way. Here, we report a 36–years–old woman presenting with unilateral thigh swelling for 1 year. She had localized lipedema of left thigh and was advised for consultation with plastic surgery department.