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Lipedema is a multifactorial pathology with a negative evolutionary trend, in which genetic, hormonal, metabolic, and vascular factors play distinct roles that are not fully understood. Inflammation is a typical feature of lipedema and can be managed by limiting glycaemic spikes. Herein, we reported a subject diagnosed with lipedema who underwent a ketogenic diet for six months, losing 12 kg, and then transitioned to a low-carb diet for a further six months, keeping the good results obtained, in terms of quality of life improvement, weight control, and pain management with low-carb. The patient was regularly trained with resistance training, which preserved and improved muscular mass. The primary and new outcome was due to the introduction of the second phase of the nutritional plan, low-carb, which could be an innovative approach. Often, diets with regular carbohydrate amounts do not give appreciable results.

Publisher: Frontiers