The mitral annulus in lipedema: Insights from the three-dimensional speckle-tracking echocardiographic MAGYAR-Path Study.

Resource type
Authors/contributors
Title
The mitral annulus in lipedema: Insights from the three-dimensional speckle-tracking echocardiographic MAGYAR-Path Study.
Abstract
INTRODUCTION: Lipedema is a barely recognized and poorly diagnosed, but common disease affecting almost exclusively female patients. The pathomechanism of lipedema is not known, and clinically, it is a bilateral, symmetrical, disproportional fatty enlargement of the lower half of the body, the disease does not affect the feet, and the upper extremities are often involved. Since lipedema is associated with increased aortic stiffness and altered left ventricular (LV) rotational mechanics, the present study was designed to compare the size and function of the mitral annulus (MA) between lipedema patients and controls by three-dimensional speckle-tracking echocardiography (3DSTE). METHODS: Twenty-four patients with stage 2 lipedema and 48 age-, gender-, and body mass index-matched healthy control patients were included in the study. Each person from the lipedema and the control groups underwent two-dimensional Doppler echocardiography and 3DSTE. RESULTS: Significantly enlarged left atrial diameter, LV end-diastolic diameter and volume, and LV end-systolic volume could be detected in lipedema patients as compared to controls. None of the lipedema patients and controls showed ≥grade 1 mitral or tricuspid regurgitation. Dilated end-systolic and end-diastolic MA diameter, area, and perimeter could be demonstrated in lipedema patients as compared to controls, and these changes were accompanied by impaired MA fractional area change at rest. Following 1-hour use of compression stockings, no significant improvement was seen in these parameters. CONCLUSIONS: Lipedema is associated with MA enlargement and functional impairment. The use of compression stockings does not improve these alterations.
Publication
Echocardiography (Mount Kisco, N.Y.)
Volume
36
Issue
8
Pages
1482-1491
Date
2019 Aug
Journal Abbr
Echocardiography
Language
eng
ISSN
1540-8175 0742-2822
Rights
© 2019 Wiley Periodicals, Inc.
Extra
Place: United States
Citation
Nemes, A., Kovács, Z., Kormányos, Á., Domsik, P., Kalapos, A., Piros, G. Á., Kemény, L., Forster, T., & Szolnoky, G. (2019). The mitral annulus in lipedema: Insights from the three-dimensional speckle-tracking  echocardiographic MAGYAR-Path Study. Echocardiography (Mount Kisco, N.Y.), 36(8), 1482–1491. https://doi.org/10.1111/echo.14429