Genetics of lipedema: new perspectives on genetic research and molecular diagnoses

Resource type
Authors/contributors
Title
Genetics of lipedema: new perspectives on genetic research and molecular diagnoses
Abstract
OBJECTIVE: The aim of this qualitative review is to provide an update on the current understanding of the genetic determinants of lipedema and to develop a genetic test to differentiate lipedema from other diagnoses. MATERIALS AND METHODS: An electronic search was conducted in MEDLINE, PubMed, and Scopus for articles published in English up to March 2019. Lipedema and similar disorders included in the differential diagnosis of lipedema were searched in the clinical synopsis section of OMIM, in GeneCards, Orphanet, and MalaCards. RESULTS: The search identified several genetic factors related to the onset of lipedema and highlighted the utility of developing genetic diagnostic testing to help differentiate lipedema from other diagnoses. CONCLUSIONS: No genetic tests or guidelines for molecular diagnosis of lipedema are currently available, despite the fact that genetic testing is fundamental for the differential diagnosis of lipedema against Mendelian genetic obesity, primary lymphedema, and lipodystrophies.
Publication
European Review for Medical and Pharmacological Sciences
Volume
23
Issue
13
Pages
5581-5594
Date
2019-07
Journal Abbr
Eur Rev Med Pharmacol Sci
Language
eng
ISSN
2284-0729
Short Title
Genetics of lipedema
Library Catalog
PubMed
Citation
Paolacci, S., Precone, V., Acquaviva, F., Chiurazzi, P., Fulcheri, E., Pinelli, M., Buffelli, F., Michelini, S., Herbst, K. L., Unfer, V., Bertelli, M., & GeneOb Project. (2019). Genetics of lipedema: new perspectives on genetic research and molecular diagnoses. European Review for Medical and Pharmacological Sciences, 23(13), 5581–5594. https://doi.org/10.26355/eurrev_201907_18292
Publication