Estrogen as a Contributing Factor to the Development of Lipedema

Resource type
Authors/contributors
Title
Estrogen as a Contributing Factor to the Development of Lipedema
Abstract
Lipedema is an underdiagnosed painful adipose tissue disorder that occurs almost exclusively in women, with onset manifesting at puberty or at times of hormonal change. Unlike many fat disorders, diet and exercise have little to no impact on the prevention or progression of this disease. Estrogens control the distribution of body fat and food intake, regulate leptin expression, increase insulin sensitivity, and reduce inflammation through signaling pathways mediated by its receptors, estrogen receptor alpha (ERα) and ERβ. This review will focus on understanding the role of estrogen in the pathogenesis of the disease and envisage potential hormonal therapy for lipedema patients.
Book Title
Physiology and Disorders of Adipose Tissue
Publisher
IntechOpen
Date
2021-02-18
Language
en
Accessed
2/20/21, 4:24 PM
Library Catalog
Extra
Publisher: IntechOpen
Lipedema Foundation Award
LF09A-T
Citation
Al-Ghadban, S., Teeler, M. L., & Bunnell, B. A. (2021). Estrogen as a Contributing Factor to the Development of Lipedema. In Physiology and Disorders of Adipose Tissue. IntechOpen. https://www.intechopen.com/online-first/estrogen-as-a-contributing-factor-to-the-development-of-lipedema