Is the endotoxin–complement cascade the major driver in lipedema?

Resource type
Authors/contributors
Title
Is the endotoxin–complement cascade the major driver in lipedema?
Abstract
Lipedema is a poorly understood disorder of adipose tissue characterized by abnormal but symmetrical deposition of subcutaneous white adipose tissue (WAT) in proximal extremities. Here, we propose that the underlying cause for lipedema could be triggered by a selective accumulation of bacterial lipopolysaccharides (LPS; also known as endotoxin) in gluteofemoral WAT. Together with a malfunctioning complement system, this induces low-grade inflammation in the depot and raises its uncontrollable expansion. Correspondingly, more attention should be paid in future research to the endotoxemia prevalent in patients with lipedema. We would like to propose that proper management of endotoxemia can reduce the progression and even improve the state of disease in patients with lipedema.
Publication
Trends in Endocrinology & Metabolism
Date
2024-04-29
Journal Abbr
Trends in Endocrinology & Metabolism
ISSN
1043-2760
Accessed
5/1/24, 2:08 PM
Library Catalog
ScienceDirect
Citation
Kruglikov, I. L., & Scherer, P. E. (2024). Is the endotoxin–complement cascade the major driver in lipedema? Trends in Endocrinology & Metabolism. https://doi.org/10.1016/j.tem.2024.04.004
Publication